Gunshots were reported at about 7 p.m. outside the 7-Eleven store on Third Avenue between Pike and Pine streets,at a major bus stop, the Seattle Times reported.
Witnesses said a group of people were arguing when the gunman began to walk away, and then turned around and fired into the crowd. At least one victim was a bystander, Seattle police Assistant Chief Robert Merner said.
One of the victims has life-threatening injuries, Merner saidd, adding all of the victims, four males and one female, were taken to Harborview Medical Centre.
The shooter was still at large.